| Title | Mammary Epithelial-Myoepithelial Carcinoma: Report of a Case With HRAS and PIK3CA Mutations by Next-Generation Sequencing. |
| Publication Type | Journal Article |
| Year of Publication | 2019 |
| Authors | Baum JE, Sung K-J, Tran H, Song W, Ginter PS |
| Journal | Int J Surg Pathol |
| Volume | 27 |
| Issue | 4 |
| Pagination | 441-445 |
| Date Published | 2019 Jun |
| ISSN | 1940-2465 |
| Keywords | Adenomyoepithelioma, Aged, Biomarkers, Tumor, Biopsy, Large-Core Needle, Breast, Breast Neoplasms, Carcinoma, Intraductal, Noninfiltrating, Class I Phosphatidylinositol 3-Kinases, DNA Mutational Analysis, Female, High-Throughput Nucleotide Sequencing, Humans, Mastectomy, Segmental, Mutation, Proto-Oncogene Proteins p21(ras) |
| Abstract | We present the case of a 73-year-old woman with an epithelial-myoepithelial carcinoma of the left breast (ie, malignant adenomyoepithelioma). In both the initial needle core biopsy and in the subsequently performed lumpectomy, the tumor consisted of nests of neoplastic epithelium and myoepithelium with cytologic atypia, increased mitoses, and infiltrative growth into the surrounding tissue. Mutational analysis showed oncogenic driver mutations in HRAS and PIK3CA. In this article, we describe an epithelial-myoepithelial carcinoma of the breast with focal metaplastic differentiation, an extremely rare entity, and report the results of targeted next-generation sequencing. Our patient has not shown any evidence of recurrent or metastatic disease at 29 months follow-up. |
| DOI | 10.1177/1066896918821182 |
| Alternate Journal | Int. J. Surg. Pathol. |
| PubMed ID | 30585117 |
Mammary Epithelial-Myoepithelial Carcinoma: Report of a Case With HRAS and PIK3CA Mutations by Next-Generation Sequencing.
Submitted by jpc2004 on February 5, 2020 - 4:58pm