Submitted by jpc2004 on February 5, 2020 - 4:58pm
| Title | TARGET-seq Takes Aim at Cancer Evolution through Multi-omics Single-Cell Genotyping and Transcriptomics. |
| Publication Type | Journal Article |
| Year of Publication | 2019 |
| Authors | Chaligne R, Nam AS, Landau DA |
| Journal | Mol Cell |
| Volume | 73 |
| Issue | 6 |
| Pagination | 1092-1094 |
| Date Published | 2019 03 21 |
| ISSN | 1097-4164 |
| Keywords | Genotype, Humans, Mutation, Neoplasms, Sequence Analysis, RNA, Single-Cell Analysis |
| Abstract | In this issue of Molecular Cell, Rodriguez-Meira et al. (2019) present TARGET-seq, an elegant single-cell method that genotypes somatic mutations and captures whole transcriptomes in the same tumor cells, thus paving the way to directly link somatic mutations with resulting transcriptional phenotypes in clonally diverse cancer populations. |
| DOI | 10.1016/j.molcel.2019.03.009 |
| Alternate Journal | Mol. Cell |
| PubMed ID | 30901562 |